Beilstein J. Org. Chem.2021,17, 2822–2831, doi:10.3762/bjoc.17.193
402160, China 10.3762/bjoc.17.193 Abstract Chemoselective sulfonylation and isonitrilation reactions for the divergent synthesis of valuable diarylmethylsulfones and isonitrile diarylmethanes starting from easy-to-synthesize para-quinone methides (p-QMs) and commercially abundant p
synthetic utility of this protocol was also demonstrated in the synthesis of difluoroalkylated diarylmethane 5 and diarylmethane ketone derivatives 6 and 7, which are important core structures in natural products and medicines.
Keywords: chemoselective reactions; diarylmethylsulfones; dual role
sulfones is a valuable and appealing task in synthetic chemistry.
Traditionally, diarylmethylsulfones are synthesized by transition-metal-catalyzed deoxy C–S bond-coupling reaction of sodium arylsulfinates with diarylmethanols [11], C–H functionalization of alkyl sulfones with aryl halides [12], and via a